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FOLOTYN (Pralatrexate)
FOLOTYN (Pralatrexate)
- Medicine Name: Folotyn
- Generic Name: Pralatrexate
- Dosage Form & Strength: 40 mg/2 mL single-use vial (Injection)
- Manufactured By: Allos Therapeutics, Inc.
Folotyn (Pralatrexate) is a folate analog metabolic inhibitor used for the treatment of relapsed or refractory Peripheral T-cell Lymphoma (PTCL).
It was approved by the U.S. FDA on September 24, 2009 under accelerated approval based on overall response rate. Continued approval may be contingent upon further clinical trial outcomes.
Mechanism of Action:
Pralatrexate inhibits dihydrofolate reductase (DHFR), disrupting DNA synthesis and leading to cell death in rapidly proliferating cancer cells.
Indicated For:
- Adult patients with relapsed or refractory PTCL, particularly after failure of other systemic therapies.
Recommended Administration:
- Folotyn is administered intravenously, typically once weekly for 6 weeks in a 7-week cycle.
- Supplementation with folic acid and vitamin B12 is required to reduce toxicity.
- Dose modifications may be necessary based on blood counts and adverse effects.
Mucositis: Severe and sometimes fatal mucositis has occurred. Start folic acid and vitamin B12 supplementation prior to treatment.
Myelosuppression: May cause neutropenia, thrombocytopenia, and anemia. Monitor CBC regularly.
Hepatotoxicity: Elevated liver enzymes and bilirubin have been reported. Monitor liver function tests periodically.
Renal Impairment: Patients with renal dysfunction may experience increased toxicity. Dose adjustments are required.
Dermatologic Toxicity: May cause exfoliative dermatitis, rash, or other skin reactions. Discontinue in case of severe skin events.
Embryo-Fetal Toxicity: Pralatrexate may cause fetal harm. Effective contraception is required during and after treatment.
Documents Required for Import to India:
- Valid prescription from a certified oncologist
- Patient’s diagnostic reports
- Government-issued patient ID proof
Order Confirmation:
Order will be confirmed only after receiving the above documentation and any required import permit.
Availability:
Folotyn is not available through conventional Indian pharmacies. It can be legally imported under the Named Patient Supply (NPS) program via GlobalRareMeds.
We ensure 100% transparency and regulatory compliance in every import.
GlobalRareMeds sources Folotyn (Pralatrexate) directly from certified international suppliers across Europe, USA, and Canada.
- Cold-chain compliant delivery
- Registered pharmacist review
- Dispatch from our Ambernath, Thane District Fulfillment Center
We deliver across India including:
📍 Mumbai, Delhi, Bangalore, Kolkata, Hyderabad, Ahmedabad, Chennai, Jaipur, Lucknow, and more.
📞 Call/WhatsApp: +91-99675 15602
📧 Email: info@globalraremeds.com
What is Folotyn used for?
Folotyn is used to treat patients with Peripheral T-cell Lymphoma (PTCL) who have relapsed or are not responding to standard therapies.
Is Folotyn FDA-approved?
Yes, Folotyn was approved by the FDA in 2009 under accelerated approval.
How is Folotyn administered?
It is given intravenously once weekly in 6-week cycles, typically in a hospital or clinic setting under close supervision.
What are the common side effects?
- Mouth sores (mucositis)
- Low white blood cells, platelets, and red blood cells
- Nausea, fatigue, skin rashes
- Liver enzyme elevations
Can Folotyn be legally imported to India?
Yes. With a valid prescription, GlobalRareMeds can facilitate legal import and delivery of Folotyn anywhere in India under the Named Patient Program.
What is the storage condition of Folotyn?
Store Folotyn at 2°C to 8°C. Do not freeze. Keep in original packaging to protect from light.
How much does Folotyn cost in India?
Price varies based on origin and availability.
Please contact:
📞 +91-99675 15602
📧 info@globalraremeds.com
Contact Patient Support
If you have questions about your order, need assistance with documentation, or require support with medicine availability, our GlobalRareMeds Patient Support Team is here to help. We aim to respond within 24 hours, Monday to Friday, between 9:00 AM and 10:00 AM IST.
info@globalraremeds.com
Phone
+91 99675 15602
+91 99675 15602
Disclaimer
All trademarks, brands, and product names featured on this website are the property of their respective owners. GlobalRareMeds does not claim ownership or affiliation unless explicitly stated. Our role is to provide reliable and transparent access to difficult-to-source medicines through named-patient import services, based on valid prescriptions and legal requirements.
The product-related content on this website is shared to the best of our knowledge, compiled from publicly available sources and regulatory documents. However, GlobalRareMeds does not guarantee the accuracy, completeness, or timeliness of this information. We strongly recommend that all medical decisions, including usage and dosage, be made only in consultation with the prescribing doctor. GlobalRareMeds assumes no responsibility for consequences arising from reliance on this information without appropriate medical guidance
