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Iclusig (Ponatinib Tablets)
Iclusig (Ponatinib Tablets)
- Medicine Name: Iclusig
- Generic Name: Ponatinib
- Dosage Form & Strength: 10 mg, 15 mg, 30 mg, 45 mg
- Manufactured By: Ariad Pharmaceuticals, Inc.
Iclusig (Ponatinib) is a tyrosine kinase inhibitor approved for the treatment of adults with:
- Chronic Phase (CP) Chronic Myeloid Leukemia (CML) resistant or intolerant to at least two prior TKIs
- Accelerated Phase (AP) or Blast Phase (BP) CML or Philadelphia chromosome-positive (Ph+) Acute Lymphoblastic Leukemia (ALL) where no other TKIs are indicated
- T315I-positive CML or Ph+ ALL
FDA Approval Date: December 14, 2012
How it works:
Ponatinib targets the BCR-ABL1 tyrosine kinase, including the T315I mutation, a common cause of resistance to previous CML treatments.
Dosage:
- CP-CML: Start at 45 mg once daily with or without food. Reduce to 15 mg upon achieving molecular response (BCR-ABL1 ≤1%).
- AP-CML, BP-CML, Ph+ ALL: Recommended dose is 45 mg once daily. Treatment continues until disease progression or unacceptable toxicity.
Dose adjustments should be made based on patient response or occurrence of adverse events.
Arterial Occlusive Events (AOEs): Life-threatening AOEs have been reported. Monitor closely and interrupt or discontinue if necessary.
Venous Thromboembolic Events (VTEs): Includes cases of pulmonary embolism and deep vein thrombosis. Stop therapy immediately in severe cases.
Heart Failure: Cases include decreased ejection fraction and left ventricular dysfunction. Discontinue in severe or worsening cases.
Severe Hemorrhage: May include gastrointestinal or intracranial bleeding. Monitor platelet counts; discontinue in life-threatening cases.
Hepatotoxicity: Regular liver function monitoring is advised. Interrupt or discontinue in cases of acute liver damage.
Myelosuppression: Monitor CBC routinely and adjust dosage for neutropenia, anemia, or thrombocytopenia.
Fetal Harm: Ponatinib can harm an unborn baby. Effective contraception must be used during treatment.
Breastfeeding: Not recommended while on Ponatinib due to potential harm to the infant.
Documents Required for Import to India:
- A valid prescription from a qualified oncologist
- Patient’s diagnostic reports
- Government-issued ID proof of the patient
Order Confirmation:
The order is confirmed only upon receipt of the above documents and import permit (if applicable).
Availability in India:
Iclusig (Ponatinib) is not commercially available in Indian retail pharmacies. However, through GlobalRareMeds, we facilitate import under Named Patient Supply, sourcing directly from certified distributors in the USA, Canada, Europe, and Australia.
GlobalRareMeds ensures access to Iclusig (Ponatinib) via legal and compliant sourcing for Indian patients. Our fulfillment center in Ambernath, Thane District, coordinates secure delivery to:
📍 Mumbai, Delhi, Pune, Hyderabad, Bangalore, Kolkata, Ahmedabad, Chennai, Jaipur, Lucknow, Chandigarh, and all major cities across India.
We ensure:
- 100% verified product authenticity
- Cold chain and handling compliance (if applicable)
- Full prescription audit and dispatch within regulatory norms
📞 Call/WhatsApp: +91-99675 15602
📧 Email: info@globalraremeds.com
What is Iclusig® used for?
Iclusig is used to treat CML and Ph+ ALL patients who have resistance or intolerance to at least two previous TKI treatments, or have the T315I mutation.
What forms and strengths are available?
Available in oral tablet form – 10 mg, 15 mg, 30 mg, and 45 mg.
Is Iclusig FDA-approved?
Yes, Iclusig received FDA approval on December 14, 2012.
What are the most common side effects of Iclusig?
Common side effects include:
- Fatigue
- Abdominal pain
- Rash
- Hypertension
- Dry skin
- Diarrhea
- Headache
- Pyrexia
- Nausea
- Arthralgia
- Fluid retention
How do I store Iclusig tablets?
Store at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C and 30°C. Keep in original packaging.
How can I buy Iclusig in India legally?
You can legally import Iclusig through GlobalRareMeds by submitting a valid prescription and import documents. We coordinate end-to-end logistics for individual patients and hospitals.
What’s the cost of Ponatinib in India?
Prices vary based on dosage and sourcing country. Contact us directly for a personalized quotation:
📧 info@globalraremeds.com
📞 +91-99675 15602
Contact Patient Support
If you have questions about your order, need assistance with documentation, or require support with medicine availability, our GlobalRareMeds Patient Support Team is here to help. We aim to respond within 24 hours, Monday to Friday, between 9:00 AM and 10:00 AM IST.
info@globalraremeds.com
Phone
+91 99675 15602
+91 99675 15602
Disclaimer
All trademarks, brands, and product names featured on this website are the property of their respective owners. GlobalRareMeds does not claim ownership or affiliation unless explicitly stated. Our role is to provide reliable and transparent access to difficult-to-source medicines through named-patient import services, based on valid prescriptions and legal requirements.
The product-related content on this website is shared to the best of our knowledge, compiled from publicly available sources and regulatory documents. However, GlobalRareMeds does not guarantee the accuracy, completeness, or timeliness of this information. We strongly recommend that all medical decisions, including usage and dosage, be made only in consultation with the prescribing doctor. GlobalRareMeds assumes no responsibility for consequences arising from reliance on this information without appropriate medical guidance
