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Rylaze
Rylaze
- Medicine Name: Rylaze
- Generic Name: Asparaginase Erwinia Chrysanthemi (recombinant)-rywn
- Dosage Form & Strength: Injection – 10 mg/0.5 mL solution in a single-dose vial
- Manufactured By: Jazz Pharmaceuticals
Rylaze is an asparagine-specific enzyme indicated as part of a multi-agent chemotherapeutic regimen for:
- Acute lymphoblastic leukemia (ALL)
- Lymphoblastic lymphoma (LBL)
It is specifically used in adult and pediatric patients (aged 1 month and older) who are hypersensitive to E. coli-derived asparaginase.
Recommended Dosage:
When substituting a long-acting asparaginase product, the recommended dosage is 25 mg/m², administered intramuscularly every 48 hours.
Severe hypersensitivity reactions, including life-threatening anaphylaxis, can occur. Administer Rylaze in a clinical setting with emergency resuscitation equipment available.
Thrombotic events such as sagittal sinus thrombosis and pulmonary embolism have been reported. Discontinue Rylaze in case of thrombosis and consider anticoagulation therapy. Resume only if the thrombosis is uncomplicated.
Pancreatitis is a known risk. Monitor patients for relevant symptoms. Evaluate serum amylase and lipase levels in suspected cases.
Risk of hemorrhage and coagulopathy due to altered PT, PTT, and fibrinogen levels. Provide supportive therapy in symptomatic patients.
Hepatotoxicity may present as elevated bilirubin and liver enzymes. Monitor liver function every 2–3 weeks. Discontinue if severe hepatic
To import Rylaze (Asparaginase Erwinia Chrysanthemi recombinant) via GlobalRareMeds, the followingdocuments are required:
- Valid prescription from a qualified oncologist or hematologist
- Diagnostic reports confirming ALL or LBL with E. coli-asparaginase hypersensitivity
- Patient’s government-issued ID proof
Order Confirmation:
Orders are confirmed only after verification of prescription and documentation. An import permit may be required based on regulatory norms.
GlobalRareMeds sources Rylaze injection (10 mg/0.5 mL) from certified global distributors in the USA, Canada, Europe, and Australia.
Our fulfillment center in Ambernath, Thane District ensures secure processing, cold chain compliance, and dispatch after pharmacist validation.
Delivery is available across:
- India – Mumbai, Delhi, Bangalore, Chennai, Hyderabad, Pune, Kolkata, Ahmedabad, and other major cities
- Global destinations, depending on local import regulations
📧 Email: info@globalraremeds.com
📞 Call/WhatsApp: +91-99675 15602
Q. What is the generic name of Rylaze?
A. The generic name is Asparaginase Erwinia Chrysanthemi (recombinant)-rywn.
Q. Who manufactures Rylaze?
A. Rylaze is manufactured by Jazz Pharmaceuticals.
Q. When was Rylaze approved by the FDA?
A. Rylaze was approved by the U.S. FDA on June 30, 2021.
Q. What is Rylaze used for?
A. Rylaze is used to treat acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) in patients with hypersensitivity to E. coli-derived asparaginase.
Q. What dosage form is Rylaze available in?
A. Rylaze is supplied as a 10 mg/0.5 mL solution in a single-dose vial for intramuscular injection.
Q. What are the common side effects of Rylaze?
A. Common side effects include:
Hypersensitivity reactions, elevated liver enzymes, pyrexia, nausea, headache, fatigue, infection, bleeding, hyperglycemia, musculoskeletal pain, and stomatitis.
Q. Can Rylaze be used during pregnancy or breastfeeding?
A. There is limited data. Use only if clearly needed and under medical supervision. Breastfeeding should be avoided during treatment.
Q. How should Rylaze be stored?
A. Store in a refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze or shake. Keep in the original carton to protect from light.
Q. How can I access Rylaze in India?
A. Contact GlobalRareMeds with a valid prescription. We will facilitate the legal and secure import of Rylaze to your location.
Contact Patient Support
If you have questions about your order, need assistance with documentation, or require support with medicine availability, our GlobalRareMeds Patient Support Team is here to help. We aim to respond within 24 hours, Monday to Friday, between 9:00 AM and 10:00 AM IST.
info@globalraremeds.com
Phone
+91 99675 15602
+91 99675 15602
Disclaimer
All trademarks, brands, and product names featured on this website are the property of their respective owners. GlobalRareMeds does not claim ownership or affiliation unless explicitly stated. Our role is to provide reliable and transparent access to difficult-to-source medicines through named-patient import services, based on valid prescriptions and legal requirements.
The product-related content on this website is shared to the best of our knowledge, compiled from publicly available sources and regulatory documents. However, GlobalRareMeds does not guarantee the accuracy, completeness, or timeliness of this information. We strongly recommend that all medical decisions, including usage and dosage, be made only in consultation with the prescribing doctor. GlobalRareMeds assumes no responsibility for consequences arising from reliance on this information without appropriate medical guidance
